National Journal Club - September 2021

Topic: On Shaky Ground: Predicting Seizures in Bupropion Toxicity
Presented By: Harvard Medical Toxicology Fellowship Program, led by Dr. Michele Burns

1. Starr P, Klein-Schwartz W, Spiller H, Kern P, Ekleberry SE, Kunkel S. Incidence and onset of delayed seizures after overdoses of extended-release bupropion. Am J Emerg Med 2009; 27 (8): 911-915.
2. Beuhler MC, Spiller HA, Sasser HC. The outcome of unintentional pediatric bupropion ingestions: a NPDS database review. J Med Toxicol 2010; 6 (1): 4-8.
3. Offerman S, Levine M, Gosen J, Thomas SH. Pediatric bupropion ingestions in adolescents vs. younger children- a tale of two populations. J Med Toxicol 2020; 16 (1): 6-11.
4. Offerman S, Gosen J, Thomas SH, Padilla-Jones A, Ruha AM, Levine M. Bupropion associated seizures following acute overdose: who develops late seizures. Clin Toxicol 2020; 58 (12): 1306-1312.
5. Rianprakaisang TN, Prather CT, Lin AL, Murray BP, Hendrickson RG & TOXIC. Factors associated with seizure development after bupropion overdose: a review of the toxicology investigators consortium. Clin Toxicol 2021; epub ahead of print.

Series Moderator: Steven E. Aks, DO, FACEP, FACMT, Toxikon Consortium

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