National Journal Club - September 2020

Topic: Fomepizole and Acetaminophen
Presented By: Washington University Medical Toxicology Program, led by Dr. Christopher Hoyte

1. Shah KR, Beuhler MC: Fomepizole as an adjunctive treatment in severe acetaminophen toxicity. Am J Emerg Med 2020;410.e5-410.e6. Akakpo JY, Ramachandran A, Duan L, et al: Delayed treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-Jun n-terminal kinase. Toxicolog Sci 2019;170:57-68.
2. Akakpo JY, Ramachandran A, Kandel SE, et al: 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice and primary human hepatocytes. Hum Exp Toxicol 2018;37:1310-1322. Min Kang A, Padilla-Jones A, Fisher ES, et al: The effect of 4-methylpyrazole on oxidative metabolism of acetaminophen in human volunteers. J Med Toxicol 2020;16:169-176.

Series Moderator: Steven E. Aks, DO, FACEP, FACMT, Toxikon Consortium

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