National Journal Club - May 2022

Topic: Carnitine in Valproic Acid Poisoning
Presented By: Indiana University program, led by Dr. Louise Kao

1. Lheureux PE, Hantson P. Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol (Phila). 2009 Feb;47(2):101-11. doi: 10.1080/15563650902752376. PMID: 19280426.
2. Glatstein M, Bonifacio Rino P, de Pinho S, Scolnik D, Pivko-Levi D, Hoyte C. Levocarnitine for the Treatment of Valproic Acid-Induced Hyperammonemic Encephalopathy in Children: The Experience of a Large, Tertiary Care Pediatric Hospital and a Poison Center. Am J Ther. 2019 May/Jun;26(3):e344-e349. doi: 10.1097/MJT.0000000000000706. PMID: 29232283.
3. Perrott J, Murphy NG, Zed PJ. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Ann Pharmacother. 2010 Jul-Aug;44(7-8):1287-93. doi: 10.1345/aph.1P135. Epub 2010 Jun 29. PMID: 20587742.
4. Nguyen P, Chevillard L, Gouda AS, Gourlain H, Labat L, Malissin I, Deye N, Voicu S, Mégarbane B. L-carnitine does not improve valproic acid poisoning management: a cohort study with toxicokinetics and concentration/effect relationships. Ann Intensive Care. 2022 Jan 29;12(1):7. doi: 10.1186/s13613-022-00984-z. PMID: 35092514; PMCID: PMC8800998.

Series Moderator: Steven E. Aks, DO, FACEP, FACMT, Toxikon Consortium

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