National Journal Club - May 2022

National Journal Club - May 2022

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Topic: Carnitine in Valproic Acid Poisoning
Presented By: Indiana University program, led by Dr. Louise Kao

  1. Lheureux PE, Hantson P. Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol (Phila). 2009 Feb;47(2):101-11. doi: 10.1080/15563650902752376. PMID: 19280426.
  2. Glatstein M, Bonifacio Rino P, de Pinho S, Scolnik D, Pivko-Levi D, Hoyte C. Levocarnitine for the Treatment of Valproic Acid-Induced Hyperammonemic Encephalopathy in Children: The Experience of a Large, Tertiary Care Pediatric Hospital and a Poison Center. Am J Ther. 2019 May/Jun;26(3):e344-e349. doi: 10.1097/MJT.0000000000000706. PMID: 29232283.
  3. Perrott J, Murphy NG, Zed PJ. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Ann Pharmacother. 2010 Jul-Aug;44(7-8):1287-93. doi: 10.1345/aph.1P135. Epub 2010 Jun 29. PMID: 20587742.
  4. Nguyen P, Chevillard L, Gouda AS, Gourlain H, Labat L, Malissin I, Deye N, Voicu S, M├ęgarbane B. L-carnitine does not improve valproic acid poisoning management: a cohort study with toxicokinetics and concentration/effect relationships. Ann Intensive Care. 2022 Jan 29;12(1):7. doi: 10.1186/s13613-022-00984-z. PMID: 35092514; PMCID: PMC8800998.

Series Moderator: Steven E. Aks, DO, FACEP, FACMT, Toxikon Consortium

About The Series: ACMT's National Journal Club (NJC) is a bimonthly member webinar hosted by a different fellowship program each session. All data and information provided in this activity is for informational purposes only. ACMT makes no representations as to accuracy, completeness, currentness, suitability, or validity of the content and will not be liable for any errors or omissions in this information or any losses, injuries, or damages arising from its display or use.

This webinar is for ACMT members only.


National Journal Club - May 2022
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