National Grand Rounds - April 2025
Includes a Live Web Event on 04/22/2025 at 12:00 PM (EDT)
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Understanding FDA Warnings: Cardiac Risks of Lamotrigine and Safe Management Strategies for Clinicians
Presenter: David S. Auerbach, PhD, Assistant Professor of Pharmacology, SUNY Upstate Medical University
Join ACMT on Tuesday, April 22, 2025 at 12pm ET for a National Grand Rounds featuring Dr. David Auerbach as he addresses the FDA's safety advisory regarding lamotrigine and its potential cardiac effects. This important session, informed by research from the Ad Hoc ILAE/AES Task Force, will focus on lamotrigine's class IB antiarrhythmic properties and the associated risks for patients with certain cardiac conditions. Dr. Auerbach will outline the updated warnings added to the drug's label, offer practical guidelines for safe use, and discuss key considerations for healthcare providers managing patients on lamotrigine therapy.
Learning Objectives
- Identify the FDA safety warnings regarding the cardiac effects of lamotrigine and understand the specific patient populations at increased risk for proarrhythmic events.
- Apply updated clinical guidelines and practical strategies to safely manage lamotrigine therapy in patients, particularly those with pre-existing cardiac conditions, to minimize potential cardiac safety risks.
About The Series: ACMT's Grand Rounds offer an in-depth and interactive platform for learning and discussion about issues that impact the research and practice of medical toxicology. Experts from within and outside medical toxicology will share their knowledge and experience and highlight areas for collaboration and mutual understanding.
This webinar is for ACMT members only.
David S. Auerbach, PhD
Assistant Professor of Pharmacology
SUNY Upstate Medical University
Dr. David Auerbach is an Assistant Professor of Pharmacology at SUNY Upstate Medical University and Adjunct Assistant Professor of Medicine at the University of Rochester Medical Center, specializing in the overlap of cardiac and neurological disorders. He earned his bachelor’s degree in Human Physiology from Skidmore College, followed by a master’s in Physiology and Biophysics at Case Western Reserve University, and a Ph.D. in Pharmacology from SUNY Upstate, where his research advanced the understanding of cardiac arrhythmia mechanisms. During his postdoctoral fellowship at the University of Michigan, he demonstrated that severe genetic forms of epilepsy also affect cardiac function, linking seizures to arrhythmias. In 2019, Dr. Auerbach returned to SUNY Upstate to establish his own research team, focusing on the multi-system factors underlying Sudden Unexpected Death in Epilepsy (SUDEP). He frequently lectures at scientific meetings and patient advocacy events, driven by a commitment to understanding and addressing the cross-system impact of genetic electrical diseases.
Nicholas E. Nacca, MD, FACMT (Moderator)
Assistant Professor of Emergency Medicine, Director of Medical Toxicology, Associate Fellowship Director of Medical Toxicology Fellowship Program
University of Rochester Medical Center
Dr. Nacca is the director of Medical Toxicology and Medical Toxicology Fellowship Director at the University of Rochester Medical Center. In addition to being faculty member in the Department of Emergency Medicine he holds a secondary appointment in the Department of Environmental Medicine. His primary role is staffing the educational and clinical medical toxicology consultation service, with educational responsibilities to medical toxicology fellows, multidisciplinary teams of medical residents, pharmacy residents and students, as well as medical students. He staffs and directs a referral based outpatient Medical Toxicology Clinic.